Sequential chemotherapy and radiation for nasopharyngeal cancer: absence of long-term benefit despite a high rate of tumor response to chemotherapy.

@article{Tannock1987SequentialCA,
  title={Sequential chemotherapy and radiation for nasopharyngeal cancer: absence of long-term benefit despite a high rate of tumor response to chemotherapy.},
  author={Ian F. Tannock and David C. Payne and Brittany Cummings and Karen L. Hewitt and Thomas Panzarella},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1987},
  volume={5 4},
  pages={
          629-34
        }
}
Between April 1981 and December 1983, patients with locoregional carcinoma of the nasopharynx were treated with two courses of chemotherapy administered before radiation therapy. Chemotherapy consisted of methotrexate, bleomycin, and cisplatin, which were administered at 3-week intervals, and radiation therapy was scheduled to commence 3 weeks after the start of the second course. Forty-nine of 51 consecutive patients were treated; only one patient progressed on chemotherapy, and of 36 patients… CONTINUE READING
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