Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.

@article{Massimino2005SequentialCH,
  title={Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.},
  author={Maura Massimino and Lorenza Gandola and Roberto Luksch and Filippo Spreafico and D Riva and Carlo N Solero and Felice Giangaspero and Franco Locatelli and Marta Giorgia Podda and Fabio Bozzi and Emanuele Pignoli and Paola Collini and Graziella S Cefalo and Marco Zecca and Michela Casanova and Andrea Ferrari and Monica Terenziani and Cristina Meazza and Daniela Polastri and Davide Scaramuzza and Fernando Ravagnani and Franca Fossati-Bellani},
  journal={Neuro-oncology},
  year={2005},
  volume={7 1},
  pages={41-8}
}
Childhood malignant gliomas are rare, but their clinical behavior is almost as aggressive as in adults, with resistance to therapy, rapid progression, and not uncommonly, dissemination. Our study protocol incorporated sequential chemotherapy and high-dose thiotepa in the preradiant phase, followed by focal radiotherapy and maintenance with vincristine and… CONTINUE READING