Sequential chemoimmunotherapy with cisplatin, interferon-beta and interleukin-2 inhibits the growth of B16-F1 melanoma in syngeneic mice.

@article{Kubo2000SequentialCW,
  title={Sequential chemoimmunotherapy with cisplatin, interferon-beta and interleukin-2 inhibits the growth of B16-F1 melanoma in syngeneic mice.},
  author={Hitomi Kubo and Kenichi Hirakata Matsumoto and Makoto Funahashi and Hitoshi Takagi and Yoshimitu Kitajima and Shigeki Taniguchi and Toshiaki Saida},
  journal={Melanoma research},
  year={2000},
  volume={10 3},
  pages={
          223-9
        }
}
Sequential combinations of chemotherapy with biological response modifiers has recently been evaluated as systemic treatment for patients with advanced melanoma. The response rates of the chemoimmunotherapy were reported to be higher than conventional treatment using chemotherapy or biological agents alone. To investigate the effectiveness of such chemoimmunotherapy, we evaluated the antitumour effect of sequential chemoimmunotherapy in vivo using a B16 mouse melanoma system. In this sequential… CONTINUE READING
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