Sequential changes at differentiation gene promoters as they become active in a stem cell lineage.

@article{Chen2011SequentialCA,
  title={Sequential changes at differentiation gene promoters as they become active in a stem cell lineage.},
  author={Xin Chen and Chenggang Lu and Jose Rafael Morillo Prado and Suk Ho Eun and Margaret T Fuller},
  journal={Development},
  year={2011},
  volume={138 12},
  pages={2441-50}
}
Transcriptional silencing of terminal differentiation genes by the Polycomb group (PcG) machinery is emerging as a key feature of precursor cells in stem cell lineages. How, then, is this epigenetic silencing reversed for proper cellular differentiation? Here, we investigate how the developmental program reverses local PcG action to allow expression of terminal differentiation genes in the Drosophila male germline stem cell (GSC) lineage. We find that the silenced state, set up in precursor… CONTINUE READING
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