Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes

Abstract

Gene expression in skeletal muscle is controlled by a family of basic helix-loop-helix transcription factors known as the myogenic regulatory factors (MRFs). The MRFs work in conjunction with E proteins to regulate gene expression during myogenesis. However, the precise mechanism by which the MRFs activate gene expression is unclear. In this work, we sought… (More)
DOI: 10.1186/2044-5040-1-14

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