Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients.

@article{Portmann1985SequentialAD,
  title={Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients.},
  author={Bernard Portmann and Hans Popper and James Neuberger and Roger Williams},
  journal={Gastroenterology},
  year={1985},
  volume={88 6},
  pages={1777-90}
}
Four forms of piecemeal necrosis--biliary, lymphocytic, ductular, and fibrotic--were identified in 605 liver biopsy specimens from 209 patients with primary biliary cirrhosis. Whereas lymphocytic piecemeal necrosis, often associated with lobular hepatitis, was most common in stages 2 and 3 of the classical histologic staging, biliary piecemeal necrosis was frequent in all stages, except stage 1, and the fibrotic form appeared to be a late, mainly cirrhotic feature. In 77% of patients… CONTINUE READING

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