Sequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanoma.


There is increasing experimental evidence to suggest that expression of O6-alkylguanine-DNA-alkyltransferase (ATase) is a major factor in resistance to dacarbazine (DTIC). We recently demonstrated a progressive ATase depletion in human peripheral lymphocytes with nadir levels occurring at 4-6 h after DTIC administration (Lee et al., 1991). Therefore in an… (More)
DOI: 10.1038/bjc.1993.251

6 Figures and Tables


  • Presentations referencing similar topics