Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium.

@article{Rupper2001SequentialAO,
  title={Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium.},
  author={Adam C Rupper and K Lee and David A. Knecht and James Cardelli},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 9},
  pages={
          2813-24
        }
}
Macropinocytosis plays an important role in the internalization of antigens by dendritic cells and is the route of entry for many bacterial pathogens; however, little is known about the molecular mechanisms that regulate the formation or maturation of macropinosomes. Like dendritic cells, Dictyostelium amoebae are active in macropinocytosis, and various proteins have been identified that contribute to this process. As described here, microscopic analysis of null mutants have revealed that the… CONTINUE READING