Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis.

@article{Sapir1998SequentialAO,
  title={Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis.},
  author={Amir Sapir and Ronen Schweitzer and Ben-Zion Shilo},
  journal={Development},
  year={1998},
  volume={125 2},
  pages={191-200}
}
Previous work has demonstrated a role for the Drosophila EGF receptor (Torpedo/DER) and its ligand, Gurken, in the determination of anterioposterior and dorsoventral axes of the follicle cells and oocyte. The roles of DER in establishing the polarity of the follicle cells were examined further, by following the expression of DER-target genes. One class of genes (e.g. kekon) is induced by the DER pathway at all stages. Broad expression of kekon at the stage in which the follicle cells migrate… CONTINUE READING
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