Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.

@article{Moubarak2007SequentialAO,
  title={Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.},
  author={Rana S. Moubarak and Victor J Yuste and C{\'e}dric Artus and A{\"i}da Bouharrour and Peter A. Greer and Josiane M{\'e}nissier-de Murcia and Santos A Susin},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 13},
  pages={4844-62}
}
Alkylating DNA damage induces a necrotic type of programmed cell death through the poly(ADP-ribose) polymerases (PARP) and apoptosis-inducing factor (AIF). Following PARP activation, AIF is released from mitochondria and translocates to the nucleus, where it causes chromatin condensation and DNA fragmentation. By employing a large panel of gene knockout cells, we identified and describe here two essential molecular links between PARP and AIF: calpains and Bax. Alkylating DNA damage initiated a… CONTINUE READING
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