Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge.

@article{Norden2016SequentialAO,
  title={Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge.},
  author={Diana M. Norden and Paige J. Trojanowski and Emmanuel Moreno Villanueva and Elisa Soto Navarro and Jonathan P Godbout},
  journal={Glia},
  year={2016},
  volume={64 2},
  pages={
          300-16
        }
}
Activation of the peripheral immune system elicits a coordinated response from the central nervous system. Key to this immune to brain communication is that glia, microglia, and astrocytes, interpret and propagate inflammatory signals in the brain that influence physiological and behavioral responses. One issue in glial biology is that morphological analysis alone is used to report on glial activation state. Therefore, our objective was to compare behavioral responses after in vivo immune… CONTINUE READING
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