Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling.

Abstract

How signal transduction, which is dynamic and fluctuating by nature, is converted into a stable trancriptional response, is an unanswered question in developmental biology. Two ETS-domain transcription factors encoded by the pointed (pnt) locus, PntP1 and PntP2, are universal downstream mediators of EGFR-based signaling in Drosophila. Full disruption of pnt… (More)
DOI: 10.1242/dev.093138

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