Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations.

@article{Morgan2005SequentialAO,
  title={Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations.},
  author={Sheila M. Morgan and Paula M O'connor and Paul D Cotter and R Paul Ross and C. Ray Hill},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 7},
  pages={
          2606-11
        }
}
Lacticin 3147 is a two-peptide (LtnA1 and LtnA2) lantibiotic produced by Lactococcus lactis subsp. lactis DPC3147 and has inhibitory activity against all gram-positive microorganisms tested. In this study the specific activities of the component peptides (alone or in combination) were determined by using L. lactis subsp. cremoris HP as the target strain. Lacticin 3147 exhibited an MIC50 of 7 nM for each component peptide (in combination), suggesting a peptide stoichiometry of 1:1. Interestingly… CONTINUE READING
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