Sequential actions of BMP receptors control neural precursor cell production and fate.

@article{Panchision2001SequentialAO,
  title={Sequential actions of BMP receptors control neural precursor cell production and fate.},
  author={David M. Panchision and James M. Pickel and Lorenz P Studer and Sang Hyun Lee and Patricia Arlene Turner and Thomas G. Hazel and R. D. G. Mckay},
  journal={Genes & development},
  year={2001},
  volume={15 16},
  pages={
          2094-110
        }
}
Bone morphogenetic proteins (BMPs) have diverse and sometimes paradoxical effects during embryonic development. To determine the mechanisms underlying BMP actions, we analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor cells in vitro and in vivo. Neural precursor cells always express Bmpr-1a, but Bmpr-1b is not expressed until embryonic day 9 and is restricted to the dorsal neural tube surrounding the source of BMP ligands. BMPR-IA activation… CONTINUE READING
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