Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.

@article{Jimenez1999SequentialAO,
  title={Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.},
  author={Ramon E. Jimenez and Andrew Louis Warshaw and Kaspar Z'graggen and W. Hartwig and David Taylor and Carolyn C. Compton and Carlos Fern{\'a}ndez-del Castillo},
  journal={Annals of surgery},
  year={1999},
  volume={230 4},
  pages={501-9; discussion 509-11}
}
OBJECTIVE Pancreatic mucinous cystic neoplasms (MCNs) provide a spectrum of neoplastic changes ranging from benign to malignant. The authors have correlated K-ras mutations and p53 overexpression with the evolution of these tumors. METHODS Areas of mild, moderate, or severe dysplasia were microdissected from paraffin-embedded tissue sections of 28 different MCNs (10 benign, 9 borderline, 9 malignant). Nonneoplastic pancreatic ducts were also microdissected from tissues adjacent to the tumors… CONTINUE READING

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