Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity

@inproceedings{Sun2013SequentialWO,
  title={Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity},
  author={Peifang Sun and Josefina Garc{\'i}a and Guillermo Comach and Maryanne T. Vahey and Zhining Wang and Brett M. Forshey and Amy C Morrison and Gloria Sierra and Isabel Baz{\'a}n and Cl{\'a}udio F.K. da Rocha and Stalin Vilcarromero and Patrick Blair and Thomas W. Scott and Dar{\'i}a Elena Camacho and Christian F. Ockenhouse and Eric S. Halsey and Tadeusz J. Kochel},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
BACKGROUND Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, especially during the early days, remains poorly characterized. Early diagnostic markers for DHF are also lacking. METHODOLOGY/PRINCIPAL FINDINGS In this study, we investigated host gene expression in a cohort of DENV-infected subjects clinically… CONTINUE READING
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