Sequential Recruitment of HAT and SWI/SNF Components to Condensed Chromatin by VP16

@article{Memedula2003SequentialRO,
  title={Sequential Recruitment of HAT and SWI/SNF Components to Condensed Chromatin by VP16},
  author={Sevinci Memedula and Andrew S Belmont},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={241-246}
}
Eukaryotic transcription initiation requires the complex dynamics of hundreds of proteins, many of which are found in large multisubunit complexes. Recent experiments have suggested stepwise recruitment of preassembled complexes, including chromatin remodeling, general transcription factor, mediator, and polymerase complexes, in which the actual order of recruitment may vary for different promoters. How do these complexes access target sequences contained within tightly condensed chromatin… CONTINUE READING

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