Sequential Methods for Comparative Effectiveness Experiments : Point of Care Clinical Trials

@inproceedings{Shih2013SequentialMF,
  title={Sequential Methods for Comparative Effectiveness Experiments : Point of Care Clinical Trials},
  author={M Shih and Philip W. Lavori},
  year={2013}
}
The goal of comparative effectiveness research (CER) is to support evidence-based choices of treatments. Currently the majority of randomized trials for CER are designed to demonstrate superiority, which often require large sample size because the effect sizes between treatments in current use are typically small to moderate and there are usually more than two treatments to be compared. We propose an alternative group sequential design for such setting. Instead of testing superiority, we aim to… CONTINUE READING

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