Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms.

@article{Cupisti2003SequentialFA,
  title={Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms.},
  author={Susanne Cupisti and Clare M. Conn and Elpida Fragouli and Katherine M. Whalley and John A. Mills and Michael J. W. Faed and Joy D. A. Delhanty},
  journal={Prenatal diagnosis},
  year={2003},
  volume={23 8},
  pages={663-8}
}
OBJECTIVES Constitutional aneuploidy occurs in at least 5% of recognised pregnancies, with apparent preferential involvement of the X chromosome and the smaller autosomes. Molecular cytogenetic investigations of cleavage-stage embryos have revealed anomalies affecting all sizes of chromosomes. The aim was to investigate the variety of anomalies arising during maternal meiosis I by analysis of unfertilised oocytes and polar bodies to gain insight into aneuploidy mechanisms. METHODS Sequential… CONTINUE READING

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