Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma

@inproceedings{Westhoff2013SequentialDI,
  title={Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma},
  author={Mike-Andrew Westhoff and Najmeh Faham and Daniela Marx and Lisa Nonnenmacher and Claudia Jennewein and Stefanie Enzenm{\"u}ller and Patrick Gonzalez and Simone Fulda and K -M Debatin},
  booktitle={PloS one},
  year={2013}
}
Breaking resistance to chemotherapy is a major goal of combination therapy in many tumors, including advanced neuroblastoma. We recently demonstrated that increased activity of the PI3K/Akt network is associated with poor prognosis, thus providing an ideal target for chemosensitization. Here we show that targeted therapy using the PI3K/mTOR inhibitor NVP-BEZ235 significantly enhances doxorubicin-induced apoptosis in neuroblastoma cells. Importantly, this increase in apoptosis was dependent on… CONTINUE READING
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