Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.


BACKGROUND AND AIMS Although aberrant methylation of key genes in the progression of colorectal neoplasia has been reported, no model-based analysis of the incremental changes through the intermediate adenoma stage has been described. In addition, the biological drivers for these methylation changes have yet to be defined. Linear mixed-effects modelling was… (More)
DOI: 10.1136/gut.2010.223602

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