Sequential Changes in the Relative Affinity of Antibodies Synthesized during the Immune Response

@article{Steiner1967SequentialCI,
  title={Sequential Changes in the Relative Affinity of Antibodies Synthesized during the Immune Response},
  author={Lisa A. Steiner and Herman N. Eisen},
  journal={The Journal of Experimental Medicine},
  year={1967},
  volume={126},
  pages={1161 - 1183}
}
The anti-2,4-dinitrophenyl (DNP) antibodies synthesized by suspensions of lymph node cells obtained at various intervals from rabbits that had been immunized with DNP-bovine gamma-globulin increased progressively in their affinity for the dinitrophenyl determinant. This change accompanied and was apparently responsible for a similar change in the binding properties of anti-DNP antibodies isolated from the serum. The rate of change in affinity was related to the dose of immunogen: increasing the… CONTINUE READING

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