Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis

@inproceedings{Dupays2015SequentialBO,
  title={Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis},
  author={Laurent Dupays and Catherine A. Shang and Robert J. M. Wilson and Surendra Kotecha and Sophie Wood and Norma Towers and Timothy Mohun},
  booktitle={Cell reports},
  year={2015}
}
The homeobox transcription factors NKX2-5 and MEIS1 are essential for vertebrate heart development and normal physiology of the adult heart. We show that, during cardiac differentiation, the two transcription factors have partially overlapping expression patterns, with the result that as cardiac progenitors from the anterior heart field differentiate and migrate into the cardiac outflow tract, they sequentially experience high levels of MEIS1 and then increasing levels of NKX2-5. Using the… CONTINUE READING
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