Sequential Axon-Derived Signals Couple Target Survival and Layer Specificity in the Drosophila Visual System

@article{Pecot2014SequentialAS,
  title={Sequential Axon-Derived Signals Couple Target Survival and Layer Specificity in the Drosophila Visual System},
  author={Matthew Y Pecot and Yi Chen and Orkun Akin and Zhenqing Chen and C Kimberly Tsui and S Lawrence Zipursky},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={320-333}
}
  • Matthew Y Pecot, Yi Chen, +3 authors S Lawrence Zipursky
  • Published in Neuron 2014
  • Medicine, Biology
  • Neural circuit formation relies on interactions between axons and cells within the target field. While it is well established that target-derived signals act on axons to regulate circuit assembly, the extent to which axon-derived signals control circuit formation is not known. In the Drosophila visual system, anterograde signals numerically match R1-R6 photoreceptors with their targets by controlling target proliferation and neuronal differentiation. Here we demonstrate that additional axon… CONTINUE READING

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