Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

@inproceedings{Koppstein2015SequencingTC,
  title={Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation},
  author={David N. P. Koppstein and Joseph Ashour and David P. Bartel},
  booktitle={Nucleic acids research},
  year={2015}
}
The influenza polymerase cleaves host RNAs ∼10-13 nucleotides downstream of their 5' ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5' ends of A/WSN/33 (H1N1) influenza mRNAs. The sequences provided clear evidence for nascent-chain realignment during transcription initiation and revealed a strong influence of the viral template on the frequency of realignment. After… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Insight into Influenza: A Virus Cap-Snatching

VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of Host Genes in Influenza Virus Replication.

  • Current topics in microbiology and immunology
  • 2017
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Influenza A virus preferentially snatches noncoding RNA caps.

VIEW 5 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES