Sequencing technologies — the next generation

@article{Metzker2010SequencingT,
  title={Sequencing technologies — the next generation},
  author={M. L. Metzker},
  journal={Nature Reviews Genetics},
  year={2010},
  volume={11},
  pages={31-46}
}
  • M. Metzker
  • Published 2010
  • Biology, Medicine
  • Nature Reviews Genetics
Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near… Expand

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