Sequencing of the von Hippel-Lindau gene in canine renal carcinoma.

  title={Sequencing of the von Hippel-Lindau gene in canine renal carcinoma.},
  author={Barrak M. Pressler and Laurel E. Williams and Jos{\'e} Antonio Ramos-Vara and Kathleen I Anderson},
  journal={Journal of veterinary internal medicine},
  volume={23 3},
BACKGROUND Similarities in human and canine renal cell carcinoma (RCC) epidemiology and biologic behavior suggest that molecular mechanisms of tumorigenesis may be similar in both species. Approximately 75% of RCC in people are of the clear cell subtype, up to 85% of which are associated with mutation of the von Hippel-Lindau (VHL) gene. The canine VHL coding deoxyribonucleic acid (DNA) shares 90% identity with the human VHL gene. OBJECTIVE To determine whether or not RCC in dogs are… CONTINUE READING