Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence.

@article{Sadler1984SequencingOT,
  title={Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence.},
  author={Ingrid Sadler and Kitaru Suda and Gottfried Schatz and Fritz Kaudewitz and Albert Haid},
  journal={The EMBO journal},
  year={1984},
  volume={3 9},
  pages={2137-43}
}
Cytochrome c1 is a component of the mitochondrial respiratory chain in most eukaryotes. The protein is coded by nuclear DNA, synthesized as a larger precursor outside the mitochondria and then cleaved to the mature form in two successive steps during its import into the mitochondria. We have cloned the structural gene for yeast cytochrome c1 by functional complementation of a cytochrome c1-deficient yeast mutant with a yeast genomic library in the yeast-Escherichia coli 'shuttle' vector YEp 13… CONTINUE READING

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