Sequencing of oligourea foldamers by tandem mass spectrometry.

  title={Sequencing of oligourea foldamers by tandem mass spectrometry.},
  author={Katell Bathany and Neil W Owens and Gilles Guichard and Jean-Marie Schmitter},
  journal={Journal of the American Society for Mass Spectrometry},
  volume={24 3},
This study is focused on sequence analysis of peptidomimetic helical oligoureas by means of tandem mass spectrometry, to build a basis for de novo sequencing for future high-throughput combinatorial library screening of oligourea foldamers. After the evaluation of MS/MS spectra obtained for model compounds with either MALDI or ESI sources, we found that the MALDI-TOF-TOF instrument gave more satisfactory results. MS/MS spectra of oligoureas generated by decay of singly charged precursor ions… CONTINUE READING
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