Sequencing of GJB2 in Cameroonians and Black South Africans and comparison to 1000 Genomes Project Data Support Need to Revise Strategy for Discovery of Nonsyndromic Deafness Genes in Africans.

@article{Bosch2014SequencingOG,
  title={Sequencing of GJB2 in Cameroonians and Black South Africans and comparison to 1000 Genomes Project Data Support Need to Revise Strategy for Discovery of Nonsyndromic Deafness Genes in Africans.},
  author={Jason Bosch and Jean Jacques N Noubiap and Collet Dandara and Nomlindo Makubalo and Galen E.B Wright and Jean-Baka Domelevo Entfellner and Nicki Tiffin and Ambroise Wonkam},
  journal={Omics : a journal of integrative biology},
  year={2014},
  volume={18 11},
  pages={705-10}
}
Mutations in the GJB2 gene, encoding connexin 26, could account for 50% of congenital, nonsyndromic, recessive deafness cases in some Caucasian/Asian populations. There is a scarcity of published data in sub-Saharan Africans. We Sanger sequenced the coding region of the GJB2 gene in 205 Cameroonian and Xhosa South Africans with congenital, nonsyndromic deafness; and performed bioinformatic analysis of variations in the GJB2 gene, incorporating data from the 1000 Genomes Project. Amongst… CONTINUE READING
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