Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1.

@article{Conrad2001SequencingAT,
  title={Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1.},
  author={Silke Conrad and A Viertelhaus and Achim Orzechowski and Janet Hoogstraate and Kirsti Gjellan and Dieter Schrenk and Hans Martin Kauffmann},
  journal={Toxicology},
  year={2001},
  volume={156 2-3},
  pages={81-91}
}
The effects of xenobiotic drugs and toxic compounds depend largely on their kinetic properties, which can be influenced by transmembrane drug transporters like MDR1/P-glycoprotein and the drug-conjugate transporters multidrug resistance protein (MRP) 1 and 2. As the dog is a preferential species used in the pharmacological and toxicological evaluation of new drugs, we sequenced the canine MRP2 cDNA and investigated its expression in various canine tissues compared with the related transporters… CONTINUE READING
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