Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.

@article{SimnSnchez2008SequencingAO,
  title={Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.},
  author={Javier Sim{\'o}n-S{\'a}nchez and Andrew Singleton},
  journal={Human molecular genetics},
  year={2008},
  volume={17 13},
  pages={1988-93}
}
A novel heterozygous non-synonymous mutation and a novel polymorphism in OMI/HTRA2 locus have been associated with Parkinson's disease (PD) in a German population. In an attempt to replicate these results in an independent population, we analyzed the entire coding region of OMI/HTRA2 in a series of 644 North American PD cases with both young- and late-onset disease and in 828 North American neurologically normal controls. Our results show that neither of the variants previously related to PD… CONTINUE READING

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