Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation.

@article{Koeberl1995SequencesWT,
  title={Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation.},
  author={Dwight D. Koeberl and Christine L. Halbert and Anton A Krumm and A Dusty Miller},
  journal={Human gene therapy},
  year={1995},
  volume={6 4},
  pages={469-79}
}
The clotting factor VIII (FVIII) and cystic fibrosis transmembrane conductance regulator (CFTR) cDNAs have dramatically reduced levels of expression compared to clotting factor IX (FIX) and other cDNAs (100 and 1,000-fold lower, respectively), when produced in cells by using an expression vector. Part of the inhibitory signal in the FVIII cDNA has been… CONTINUE READING