Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.

@article{Munro1991SequencesWA,
  title={Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.},
  author={Sean Munro},
  journal={The EMBO journal},
  year={1991},
  volume={10 12},
  pages={
          3577-88
        }
}
The glycosyltransferase alpha-2,6-sialyltransferase (ST) is a Type II membrane protein localized to the Golgi apparatus. The first 44 amino acids of this protein were able to specify Golgi retention of a fused marker protein, lysozyme. This section of ST contains a transmembrane segment which serves as a non-cleaved signal anchor. When lysozyme was fused to an equivalent region of a cell surface protein it now appeared on the cell surface. Analysis of chimeras between the two proteins revealed… CONTINUE READING
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