Sequences that direct rat tyrosine hydroxylase gene expression.

@article{Fung1992SequencesTD,
  title={Sequences that direct rat tyrosine hydroxylase gene expression.},
  author={Brenda P. Fung and Sung Ok Yoon and Dona M. Chikaraishi},
  journal={Journal of neurochemistry},
  year={1992},
  volume={58 6},
  pages={
          2044-52
        }
}
Investigation of neuroendocrine genes has revealed that transcription is regulated via multiple DNA binding sites, including the cyclic AMP response element (CRE). We show here that for the neuronal and chromaffin-specific gene tyrosine hydroxylase (TH), a 70-bp region (-229 to -160) lacking the CRE is sufficient, in either orientation, to confer levels of chloramphenicol acetyltransferase reporter expression equivalent to or greater than that conferred by 4.8 kb of the rat TH enhancer/promoter… CONTINUE READING
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