Sequences of homologous beta-lactamases from clinical isolates of Serratia marcescens with different substrate specificities.

@article{Matsumura1998SequencesOH,
  title={Sequences of homologous beta-lactamases from clinical isolates of Serratia marcescens with different substrate specificities.},
  author={Naoto Matsumura and Shinzaburo Minami and Susumu Mitsuhashi},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 1},
  pages={176-9}
}
Genes for two group 1 beta-lactamases, SRT-1 and SST-1, were sequenced. These beta-lactamases were produced by clinical isolates of Serratia marcescens, isolates GN16694 and GN19450, respectively. The resulting enzymes were 96% identical. SRT-1 hydrolyzed oxyimino cephalosporins, but SST-1 hardly hydrolyzed them. At residue 213 in the third motif, which is conserved among group 1 beta-lactamases, SRT-1 and SST-1 had Lys and Glu, respectively. By site-directed mutagenesis, the substitution of… CONTINUE READING
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