Sequences of V kappa L subgroup light chains in Fanconi's syndrome. Light chain V region gene usage restriction and peculiarities in myeloma-associated Fanconi's syndrome.

@article{Rocca1995SequencesOV,
  title={Sequences of V kappa L subgroup light chains in Fanconi's syndrome. Light chain V region gene usage restriction and peculiarities in myeloma-associated Fanconi's syndrome.},
  author={Anna Rocca and Ahmed Amine Khamlichi and Guy Touchard and B{\'e}atrice Mougenot and Pierre Ronco and L Denoroy and S. Deret and J. L. Preud'homme and P. Aucouturier and Michel Cogn{\'e}},
  journal={Journal of immunology},
  year={1995},
  volume={155 6},
  pages={3245-52}
}
Certain monoclonal Ig light chains (LC) are responsible for marked disturbances of proximal tubule cell functions (Fanconi's syndrome, FS). In patients with FS, intracellular crystal-like inclusions containing LC determinants are commonly found in plasma cells, macrophages, and renal tubular cells. In an attempt at understanding the pathogenesis of myeloma-associated FS, we recently determined the first complete primary sequence of a kappa-LC (CHEB) responsible for the disease. We now report on… CONTINUE READING

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