Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials

@article{Sinclair1988SequencesHT,
  title={Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials},
  author={Andrew H. Sinclair and Jamie W. Foster and James A. Spencer and David C. Page and Mark S. Palmer and Peter N. Goodfellow and Jennifer A. Marshall Graves},
  journal={Nature},
  year={1988},
  volume={336},
  pages={780-783}
}
Sexual differentiation in placental mammals results from the action of a testis-determining gene encoded by the Y chromosome. This gene causes the indifferent gonad to develop as a testis, thereby initiating a hormonal cascade which produces a male phenotype1,2. Recently, a candidate for the testis-determining gene (ZFY, Y-borne zinc-finger protein) has been cloned3,4. The ZFY probe detects a male-specific (Y-linked) sequence in DNA from a range of eutherian mammals, as well as an X-linked… Expand
Genetic evidence that ZFY is not the testis-determining factor
TLDR
It is found that in 4 XX males lacking ZFY, there is exchange of Y-specific sequences next to the pseudoautosomal boundary, redefining the region in which TDF must lie. Expand
Zfy gene expression patterns are not compatible with a primary role in mouse sex determination
TLDR
It is reported here that ZFY-1 but not Zfy-2 is expressed in differentiating embryonic mouse testes, and these observations exclude bothZfy-1 and Zfy -2 as candidates for the mouse testis-determining gene. Expand
Evolution of the mammalian Y chromosome and sex-determining genes.
  • J. Graves
  • Biology, Medicine
  • The Journal of experimental zoology
  • 1998
TLDR
It is suggested here that, rather than acting as a transcriptional activator, the SRY gene acts to inhibit its paralogue SOX3, which in turn inhibits an ancient autosomal sex-determining gene SOX9. Expand
Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y
TLDR
The identification of a functional marsupial Y-linked homologue of the murine Ube1y gene establishing that Metatherian and Eutherian Y chromosomes diverged from a common ancestor is reported, indicating that U be1y plays a critical role in male development. Expand
The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc
TLDR
A detailed karyotype of A. mississippiensis is presented, together with chromosomal in situ hybridisation data localising the Zfc gene to chromosome 3, and further chromosomal mapping studies using eutherian X-linked genes may reveal conserved chromosomal regions in the alligator that have become part of the eutheria X chromosome during evolution. Expand
Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials
TLDR
Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. Expand
The candidate sex-reversing DAX1 gene is autosomal in marsupials: implications for the evolution of sex determination in mammals.
TLDR
DAX1 was located on wallaby chromosome 5p near other human Xp genes, indicating that it was originally autosomal and that it is not involved in X-linked dose-dependent sex determination in an ancestral mammal nor in marsupial sexual differentiation. Expand
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
  • J. Graves
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1995
TLDR
The addition–attrition hypothesis predicts that the pseudoautosomal region of the human X is merely the last relic of the latest addition, and evolved functions in male sex determination and differentiation distinct from the general functions of their X‐linked partners. Expand
Sex chromosomes and sex determination in weird mammals
TLDR
Variation sex-determining systems in rodents show that the action of SRY can change, as it evidently has in the mouse, andSRY can be inactivated, as in akodont rodents, or even completely superseded, asIn mole voles. Expand
Molecular mechanisms of TSD in reptiles: a search for the magic bullet.
TLDR
Cladistic analysis suggests that there are two or three major families of SRY-like genes in vertebrates in addition to sex specific SRY genes located on the Y chromosome of eutherian and marsupial mammals. Expand
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