Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin.

@article{Peters2003SequenceVO,
  title={Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin.},
  author={Ulrike Peters and Sabine Preisler-Adams and Claudia Lanvers-Kaminsky and Heribert J{\"u}rgens and Antoinette Lamprecht-Dinnesen},
  journal={Anticancer research},
  year={2003},
  volume={23 2B},
  pages={1249-55}
}
BACKGROUND Since mutations in the mitochondrial genome are associated with hearing loss, we analyzed whether sequence variations of mtDNA are associated with individual sensitivity to cisplatin-induced ototoxicity. MATERIALS AND METHODS The mtDNA of 20 patients with and 19 patients without hearing impairment under therapeutic doses of cisplatin was sequenced for mutations and characterized for haplotype by restriction analysis. RESULTS Neither the A7445G mutation, nor the 7472insC insertion… CONTINUE READING

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