Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

@article{Cohen2006SequenceVI,
  title={Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.},
  author={Jonathan C. Cohen and Eric Boerwinkle and Thomas H. Mosley and Helen H. Hobbs},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 12},
  pages={1264-72}
}
BACKGROUND A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population. METHODS We compared the incidence of CHD (myocardial infarction, fatal CHD, or coronary revascularization) over a 15-year… CONTINUE READING
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