Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.

@article{Donfack2003SequenceVI,
  title={Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.},
  author={Joseph Donfack and Paul Kogut and Sean M Forsythe and Julian Solway and Carole Ober},
  journal={The Journal of allergy and clinical immunology},
  year={2003},
  volume={111 3},
  pages={527-32}
}
BACKGROUND Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled, 7 transmembrane- spanning proteins. They are important in the development of airway hyperresponsiveness. In the lung the M3 receptor, encoded by the cholinergic receptor muscarinic 3 gene, is present in airway smooth muscle and mediates smooth muscle contraction. OBJECTIVE We considered the cholinergic receptor muscarinic 3 gene as a possible candidate gene for bronchial asthma and initiated… CONTINUE READING

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