Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease

  title={Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease},
  author={Denise Harold and Timothy R Peirce and Valentina Moskvina and Amanda Myers and Susan J. Jones and Paul Hollingworth and Pamela L. Moore and Simon Lovestone and John G. Powell and Catherine Foy and Nicola Archer and Sarah E. Walter and Amanda Edmonson and S. J. McIlroy and David Craig and Peter Anthony Passmore and Alison M. Goate and John S. Hardy and Michael O'Donovan and Julie Williams and Malcolm Liddell and Michael J Owen and Lesley Jones},
  journal={Human Genetics},
There is substantial evidence for a susceptibility gene for late-onset Alzheimer's disease (AD) on chromosome 10. One of the characteristic features of AD is the degeneration and dysfunction of the cholinergic system. The genes encoding choline acetyltransferase (ChAT) and its vesicular transporter (VAChT), CHAT and SLC18A3 respectively, map to the linked region of chromosome 10 and are therefore both positional and obvious functional candidate genes for late-onset AD. We have screened both… CONTINUE READING
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Func - tional identification of a vesicular acetylcholine transporter and its expression from a “ cholinergic ” gene locus

  • JD Erickson, H Varoqui, +6 authors TI Bonner
  • J Biol Chem
  • 1994
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