Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy.

@article{Elshamy2008SequenceVI,
  title={Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy.},
  author={Ahmed El-shamy and Motoko Nagano-Fujii and Noriko Sasase and Susumu Imoto and Soo Ryang Kim and Hak Hotta},
  journal={Hepatology},
  year={2008},
  volume={48 1},
  pages={38-47}
}
UNLABELLED A substantial proportion of hepatitis C virus (HCV)-1b-infected patients still do not respond to interferon-based therapy. This study aims to explore a predictive marker for the ultimate virological response of HCV-1b-infected patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy. Nonstructural protein 5A (NS5A) sequences of HCV in the pretreated sera of 45 patients infected with HCV-1b were analyzed. The mean number of mutations in the variable… CONTINUE READING

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