Sequence variation at the phenylalanine hydroxylase gene in the British Isles.

@article{Tyfield1997SequenceVA,
  title={Sequence variation at the phenylalanine hydroxylase gene in the British Isles.},
  author={Linda A. Tyfield and Anne Stephenson and Forrester Cockburn and Ann Harvie and Jeff L. Bidwell and N. A. P. Wood and Daniela T. Pilz and Pauline Harper and Isabel Smith},
  journal={American journal of human genetics},
  year={1997},
  volume={60 2},
  pages={388-96}
}
Using mutation and haplotype analysis, we have examined the phenylalanine hydroxylase gene in the phenylketonuria populations of four geographical areas of the British Isles: the west of Scotland, southern Wales, and southwestern and southeastern England. The enormous genetic diversity of this locus within the British Isles is demonstrated in the large number of different mutations characterized and in the variety of genetic backgrounds on which individual mutations are found. Allele… CONTINUE READING

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