Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates.

@article{Leroith2005SequenceVA,
  title={Sequence variation and immunologic cross-reactivity among Babesia bovis merozoite surface antigen 1 proteins from vaccine strains and vaccine breakthrough isolates.},
  author={Tanya Leroith and Kelly A. Brayton and J Molloy and Russell E Bock and S. A. Hines and Ala E Lew and T F Mcelwain},
  journal={Infection and immunity},
  year={2005},
  volume={73 9},
  pages={5388-94}
}
The Babesia bovis merozoite surface antigen 1 (MSA-1) is an immunodominant membrane glycoprotein that is the target of invasion-blocking antibodies. While antigenic variation has been demonstrated in MSA-1 among strains from distinct geographical areas, the extent of sequence variation within a region where it is endemic and the effect of variation on immunologic cross-reactivity have not been assessed. In this study, sequencing of MSA-1 from two Australian B. bovis vaccine strains and 14… CONTINUE READING

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