Sequence variant at 4q25 near PITX2 associates with appendicitis

@inproceedings{Kristjansson2017SequenceVA,
  title={Sequence variant at 4q25 near PITX2 associates with appendicitis},
  author={Ragnar P Kristjansson and Stefania Benonisdottir and Asmundur Oddsson and Tessel E. Galesloot and Gudmar Thorleifsson and Katja K. H. Aben and Olafur Birgir Davidsson and Stefan Jonsson and Gudny A Arnadottir and Brynjar O. Jensson and G Bragi Walters and Jon Kristinn Sigurdsson and Snaevar Sigurdsson and H. Spangsberg Holm and Dav{\'i}eth O Arnar and Gudmundur Thorgeirsson and Kristin K Alexiusdottir and Ingileif J{\'o}nsd{\'o}ttir and Unnur Thorsteinsdottir and Lambertus A Kiemeney and Thorvaldur J{\'o}nsson and Daniel Fannar Gudbjartsson and Thorunn Rafnar and Patrick Sulem and K{\'a}ri Stef{\'a}nsson},
  booktitle={Scientific Reports},
  year={2017}
}
Appendicitis is one of the most common conditions requiring acute surgery and can pose a threat to the lives of affected individuals. We performed a genome-wide association study of appendicitis in 7,276 Icelandic and 1,139 Dutch cases and large groups of controls. In a combined analysis of the Icelandic and Dutch data, we detected a single signal represented by an intergenic variant rs2129979 [G] close to the gene PITX2 associating with increased risk of appendicitis (OR = 1.15, P = 1.8 × 10… CONTINUE READING
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