Sequence variability and function of measles virus 3' and 5' ends and intercistronic regions.

@article{Crowley1988SequenceVA,
  title={Sequence variability and function of measles virus 3' and 5' ends and intercistronic regions.},
  author={Justin C. Crowley and Peter C Dowling and J P Menonna and Jon Silverman and Deborah E Schuback and S. D. Noam Cook and Benjamin M Blumberg},
  journal={Virology},
  year={1988},
  volume={164 2},
  pages={498-506}
}
Sequences critical for the activity of the measles virus (MV) RNA polymerase in transcription and replication were analyzed using a MV genomic cDNA library containing overlapping clones encompassing the entire MV genome. Clones corresponding to the 3' and 5' ends of the MV genome were identified and sequenced, and these sequences were confirmed by primer extension experiments. Neither (+) nor (-) strand leader RNAs were detected in MV-infected cell extracts, using high specific activity… CONTINUE READING

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