Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.

@article{Esposito1998SequenceSO,
  title={Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.},
  author={Diego Esposito and Robert Craigie},
  journal={The EMBO journal},
  year={1998},
  volume={17 19},
  pages={
          5832-43
        }
}
HIV-1 integrase specifically recognizes and cleaves viral end DNA during the initial step of retroviral integration. The protein and DNA determinants of the specificity of viral end DNA binding have not been clearly identified. We have used mutational analysis of the viral end LTR sequence, in vitro selection of optimal viral end sequences, and specific photocrosslinking to identify regions of integrase that interact with specific bases in the LTR termini. The results highlight the involvement… CONTINUE READING

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