Sequence specificity of trinucleoside diphosphate binding to polymerized tobacco mosaic virus protein

Abstract

The binding of trinucleoside diphosphates to long helical rods of tobacco mosaic virus (TMV) protein is shown to depend on base sequence, 5′ AAG 3′ binding being the strongest of the 25 trinucleoside diphosphate sequences measured. As TMV has a stoichiometry of three nucleotides per protein subunit, the sequence of TMV RNA suggested to be the nucleation… (More)
DOI: 10.1038/299032a0

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