Sequence specificity of mutation induced by the anti-tumor drug cisplatin in the CHO aprt gene.

@article{Boer1989SequenceSO,
  title={Sequence specificity of mutation induced by the anti-tumor drug cisplatin in the CHO aprt gene.},
  author={Johan G de Boer and Barry W. Glickman},
  journal={Carcinogenesis},
  year={1989},
  volume={10 8},
  pages={1363-7}
}
Cis-diammine dichloroplatinum (cisplatin) is an effective anti-cancer drug which forms adducts with DNA, in both bacterial and mammalian cells. It is suspected of producing tumors as well. To determine the molecular nature of genetic alterations induced by cisplatin, we cloned and sequenced cisplatin-induced mutants in the adenine phosphoribosyltransferase (aprt) gene of Chinese hamster ovary (CHO) cells. Mutation by cisplatin appears to be targeted as the sites of mutation are consistent with… CONTINUE READING

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